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Toschi V, Gallo R, Lettino M, Fallon JT, Gertz SD, Fernandez-Ortiz A, et al.Tissue factor modulates the thrombogenicity of human atherosclerotic plaques.Circulation. Thelow-magnification photomicrograph [top)showsthe entirelength ofabonemar-row corebiopsyspecimenobtainedfrom the posteriorpart oftheiliaccrestofa25-year-oldwoman withashorthistoryoffever,night sweats,fatigue, leukocytosiswith absolutelymphocytosis, splenomegaly,a positive polymerasechain reaction (PCR)for cytomegalovirus, anda clonalCD8+T lymphocyte proliferation.Theright sideofthe imageshowsdisruptionofthe bony trabeculae,an indication ofanartifactfrom needleinsertion inthe areacloseto the skin surface.Thelighter,moreeosinophilicarea nearthe tip ofthe core specimenwithoutevident bone marrow pattern representsaspiration artifact.

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