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Nitrosoureas and nitrosaminesare examples of hepatocarcinogens thought to producetumors through this mechanism (see also Chapters 14 and 15for further discussion of genotoxicity and carcinogenicity).Many chemicals that produce liver tumors are not genotoxic,however, and appear to work through epigenetic mecha-nisms. To overcome this breathing wouldhave to be interrupted for several seconds.

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Such anecdotal evidence is based on an experience that happened to be noticed, as opposedto research observations made under planned, systematic, and controlled circumstances (Gal-van, 2009).

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