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The alter-native spliced transcripts were named mdm2-a, mdm2-b, mdm2-c, mdm2-d andmdm2-e in order to contrast them with the full-length version called mdm2- [6].Since 1996 the list of mdm2 alternative spliced variants related to oncogenesis hasvastly increased (see Table 14.1). Beneficial effects arewell sustained with chronic therapy and the NYHAfunctional class of most patients is improved.Robust multicentric trials have shown thatACE inhibitors retard the progression of leftventricular systolic dysfunction and prolongsurvival of CHF patients of all grades (I to IV).Mortalility is reduced by ~ 20% in symptomaticCHF patients.

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